Technological and Physiological Barriers-overcoming Nanocarriers

Polymeric micelles, nanogels, nanoparticles, cyclodextrins and hybrid metal (gold, silver) -polymer systems with solubilizing and stabilizing capacity of active substances, sensitive to stimuli, targetable, for the delivery of drugs, gene material, or growth factors.

Supramolecular Gels

Gelling systems responsive to stimuli, poly(pseudo)rotaxane-like supramolecular cyclodextrin complexes… to prepare depot systems and syringeable implants.

Nanostructured Recognitive Cross-linked Gels

Stimuli-responsive polymer networks (micro/macro), materials with molecular recognition capacity, molecular imprinting, contact lenses for ocular drug release.

Aerogel-based Materials for Biomedical Applications

Engineering of novel aerogel designs and formats, bio-based aerogels as drug carriers for oral and pulmonary delivery, aerogels for wound healing, electroactive aerogels for tissue engineering.

Scaffolds for Regenerative Medicine

Injectable systems, electrospun fibers, 2D and 3D printed architectures, porous frameworks obtained by supercritical CO2 techniques.

Medical Devices with Functional Surfaces

Micro and nanometric coatings with polymers and enzymes, sensitive to stimuli, with specific recognition capacity, ... for localized release of active substances, antibiofilm surfaces, drug-device combination products.

Characterization of Materials and Systems for Pharmaceutical Applications

Physico-chemical and microstructural (texture, pore interconnectivity) characterization, mechanical and rheological properties of liquids, semisolids and solids, evaluation of excipients functionality, stability studies

Design and Development of Solid Dosage Forms for Immediate or Modified Release

Tablets, pellets, 3D printed dosage forms (printlets)

2D and 3D Materials Production

Electrospinning, electrospraying, 2D printing, particles obtained from gas-saturated solutions (PGSS), 3D printing.

Materials Processing using Supercritical CO2 Technology

Supercritical impregnation/extraction of bioactive agents, supercritical drying of gels, production of polymeric microparticles, sintering of polymeric structures, surface modification of nanoparticles

Artificial Intelligence Tools Applied to the Design and Development of Medicines

Use of Artificial Neural Networks, Fuzzy Logic, Genetic Algorithms or Gene Expression Programming (Artificial Neural Networks, fuzzy logic, genetic algorithms, GEP) in the design of pharmaceutical systems: extraction of information from big data, establishment of the design space of pharmaceutical systems, optimization of production processes, industrial scaling procedures.

Biocompatibility Assessment of Materials/Delivery Systems in Cell cultures and in Ex Vivo and Alternative to In Vivo Models

MTT, LDH, WST-1, HET-CAM, in ovo tests, corneal permeability and opacity…